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Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

The antisense activity of oligomers with 2′-O-methyl (2′-O-Me) phosphorothioate, 2′-O-methoxyethyl (2′-O-MOE) phosphorothioate, morpholino and peptide nucleic acid (PNA) backbones was investigated using a splicing assay in which the modified oligonucleotides blocked aberrant and restored correct spl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sazani, Peter, Kang, Shin-Hong, Maier, Martin A., Wei, Changfu, Dillman, Jennifer, Summerton, James, Manoharan, Muthiah, Kole, Ryszard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2001
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC60237/
https://ncbi.nlm.nih.gov/pubmed/11574678
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