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A cytosine analog that confers enhanced potency to antisense oligonucleotides

Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that clamps on to guanine by forming an additional hydrogen bond, was rationally designed to enhance oligonucleotide/RNA hybrid affinity. A single, con...

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Gorde:
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., Matteucci, Mark D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 1999
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22324/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097067/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3513
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