A cytosine analog that confers enhanced potency to antisense oligonucleotides

Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that clamps on to guanine by forming an additional hydrogen bond, was rationally designed to enhance oligonucleotide/RNA hybrid affinity. A single, con...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., Matteucci, Mark D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22324/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10097067/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.7.3513
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