A cytosine analog that confers enhanced potency to antisense oligonucleotides

Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that clamps on to guanine by forming an additional hydrogen bond, was rationally designed to enhance oligonucleotide/RNA hybrid affinity. A single, con...

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Bibliografiset tiedot
Päätekijät: Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., Matteucci, Mark D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The National Academy of Sciences 1999
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC22324/
https://ncbi.nlm.nih.gov/pubmed/10097067
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