Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models

Antisense oligonucleotides (ASOs) are a novel therapeutic approach to target difficult-to-drug protein classes by targeting their corresponding mRNAs. Significantly enhanced ASO activity has been achieved by the targeted delivery of ASOs to selected tissues. One example is the targeted delivery of A...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Kim, Youngsoo, Jo, Minji, Schmidt, Joanna, Luo, Xiaolin, Prakash, Thazha P., Zhou, Tianyuan, Klein, Stephanie, Xiao, Xiaokun, Post, Noah, Yin, Zhengfeng, MacLeod, A. Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731179/
https://ncbi.nlm.nih.gov/pubmed/31303442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.06.009
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