GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift their biodistribut...

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Publicado en:Mol Ther Nucleic Acids
Main Authors: Sewing, Sabine, Gubler, Marcel, Gérard, Régine, Avignon, Blandine, Mueller, Yasmin, Braendli-Baiocco, Annamaria, Odin, Marielle, Moisan, Annie
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6305803/
https://ncbi.nlm.nih.gov/pubmed/30583097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.11.005
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