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GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells
Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while reducing access to other organs. Conjugation of AONs to N-acetylgalactosamine (GalNAc) has been shown to efficiently shift their biodistribut...
Shranjeno v:
| izdano v: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Gene & Cell Therapy
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6305803/ https://ncbi.nlm.nih.gov/pubmed/30583097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.11.005 |
| Oznake: |
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