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Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
Targeted delivery of oligonucleotides to liver hepatocytes using N-acetylgalactosamine (GalNAc) conjugates that bind to the asialoglycoprotein receptor has become a breakthrough approach in the therapeutic oligonucleotide field. This technology has led to the approval of givosiran for the treatment...
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| Foilsithe in: | Mol Ther |
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| Main Authors: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American Society of Gene & Cell Therapy
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7403466/ https://ncbi.nlm.nih.gov/pubmed/32592692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.015 |
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