Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

The development of clinically relevant anti-microRNA antisense oligonucleotides (anti-miRNA ASOs) remains a major challenge. One promising configuration of anti-miRNA ASOs called “tiny LNA (tiny Locked Nucleic Acid)” is an unusually small (~8-mer), highly chemically modified anti-miRNA ASO with high...

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Udgivet i:Pharmaceutics
Main Authors: Yamamoto, Tsuyoshi, Mukai, Yahiro, Wada, Fumito, Terada, Chisato, Kayaba, Yukina, Oh, Kaho, Yamayoshi, Asako, Obika, Satoshi, Harada–Shiba, Mariko
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228246/
https://ncbi.nlm.nih.gov/pubmed/34072682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060817
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