Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides.
Antisense 2'-O-methylribooligonucleotides were targeted against specific sequence elements in mutated human beta-globin pre-mRNAs to restore correct splicing of these RNAs in vitro. The following mutations of the beta-globin gene, A-->G at nt 110 of the first intron (beta 110), T-->G at nt 705 and C...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47420/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8378346/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.18.8673 |
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