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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that produces splice variants with different functions. Such variants have been linked to a variety of cancers, and genetic diseases such as thalassemia and cystic fibrosis. This Perspective describes a prom...

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Autori principali: Sazani, Peter, Kole, Ryszard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC171400/
https://ncbi.nlm.nih.gov/pubmed/12925686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200319547
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