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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that produces splice variants with different functions. Such variants have been linked to a variety of cancers, and genetic diseases such as thalassemia and cystic fibrosis. This Perspective describes a prom...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Principais autores: Sazani, Peter, Kole, Ryszard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2003
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171400/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925686/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19547
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