Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that produces splice variants with different functions. Such variants have been linked to a variety of cancers, and genetic diseases such as thalassemia and cystic fibrosis. This Perspective describes a prom...

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Bibliografische Detailangaben

Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Sazani, Peter, Kole, Ryszard
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2003
Schlagworte:	Perspective Series
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12925686/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI19547
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