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RNA therapeutics: Beyond RNA interference and antisense oligonucleotides

Here we discuss three RNA therapeutic technologies exploiting various oligonucleotides that bind RNA by base-pairing in a sequence-specific manner yet have different mechanisms of action and effects. RNA interference and antisense oligonucleotides downregulate gene expression by enzyme-dependent deg...

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Détails bibliographiques
Publié dans:Nat Rev Drug Discov
Auteurs principaux: Kole, Ryszard, Krainer, Adrian R., Altman, Sidney
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743652/
https://ncbi.nlm.nih.gov/pubmed/22262036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd3625
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