Small-Molecule Positive Allosteric Modulators of the β(2)-Adrenoceptor Isolated from DNA-Encoded Libraries

Conventional drug discovery efforts at the β(2)-adrenoceptor (β(2)AR) have led to the development of ligands that bind almost exclusively to the receptor’s hormone-binding orthosteric site. However, targeting the largely unexplored and evolutionarily unique allosteric sites has potential for develop...

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Bibliographic Details
Published in:Mol Pharmacol
Main Authors: Ahn, Seungkirl, Pani, Biswaranjan, Kahsai, Alem W., Olsen, Eva K., Husemoen, Gitte, Vestergaard, Mikkel, Jin, Lei, Zhao, Shuai, Wingler, Laura M., Rambarat, Paula K., Simhal, Rishabh K., Xu, Thomas T., Sun, Lillian D., Shim, Paul J., Staus, Dean P., Huang, Li-Yin, Franch, Thomas, Chen, Xin, Lefkowitz, Robert J.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022804/
https://ncbi.nlm.nih.gov/pubmed/29769246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.111948
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