DisruPPI: structure-based computational redesign algorithm for protein binding disruption

MOTIVATION: Disruption of protein–protein interactions can mitigate antibody recognition of therapeutic proteins, yield monomeric forms of oligomeric proteins, and elucidate signaling mechanisms, among other applications. While designing affinity-enhancing mutations remains generally quite challengi...

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Опубликовано в: :Bioinformatics
Главные авторы: Choi, Yoonjoo, Furlon, Jacob M, Amos, Ryan B, Griswold, Karl E, Bailey-Kellogg, Chris
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Ismb 2018–Intelligent Systems for Molecular Biology Proceedings
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6022686/
https://ncbi.nlm.nih.gov/pubmed/29949961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty274
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