Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity

Background: Class IA phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) is an integral mediator of insulin signaling. The p110 catalytic and p85 regulatory subunits of PI3K are the products of separate genes, and while they come together to make the active heterodimer, they have opposing roles in...

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Publicado en:F1000Res
Autores principales: Chaudhari, Aditi, Ejeskär, Katarina, Wettergren, Yvonne, Kahn, C. Ronald, Rotter Sopasakis, Victoria
Formato: Artigo
Lenguaje:Inglês
Publicado: F1000 Research Limited 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020741/
https://ncbi.nlm.nih.gov/pubmed/29983910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.12418.2
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