p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity

The phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit p110α is the most frequently mutated kinase in human cancer, and the hot spot mutations E542K, E545K, and H1047R are the most common mutations in p110α. Very little is known about the metabolic consequences of the hot spot m...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Chaudhari, Aditi, Krumlinde, Daniel, Lundqvist, Annika, Akyürek, Levent M., Bandaru, Sashidhar, Skålén, Kristina, Ståhlman, Marcus, Borén, Jan, Wettergren, Yvonne, Ejeskär, Katarina, Rotter Sopasakis, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561724/
https://ncbi.nlm.nih.gov/pubmed/26169833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00471-15
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