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Novel all-hydrocarbon stapled p110α[E545K] peptides as blockers of the oncogenic p110α[E545K]-IRS1 interaction
To follow up on our recent discovery of the 18-amino acid all-hydrocarbon [i, i+4]-stapled p110α[E545K] peptide 1 that was shown to potently block the intracellular p110α[E545K]-IRS1 interaction (a protein-protein interaction uniquely present in cancer cells expressing p110α[E545K]) and the growth o...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5711480/ https://ncbi.nlm.nih.gov/pubmed/29138025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.10.076 |
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