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Gain of interaction with IRS1 by p110α helical domain mutants is crucial for their oncogenic functions
PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase α, is frequently mutated in human cancers. Most of these mutations occur at two hot-spots E545K and H1047R located in the helical domain and the kinase domain, respectively. Here, we report that p110α E545K, but not p...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671608/ https://ncbi.nlm.nih.gov/pubmed/23643389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.021 |
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