Gain of interaction with IRS1 by p110α helical domain mutants is crucial for their oncogenic functions

PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase α, is frequently mutated in human cancers. Most of these mutations occur at two hot-spots E545K and H1047R located in the helical domain and the kinase domain, respectively. Here, we report that p110α E545K, but not p...

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Autori principali: Hao, Yujun, Wang, Chao, Cao, Bo, Hirsch, Brett M., Song, Jing, Markowitz, Sanford D., Ewing, Rob M., Sedwick, David, Liu, Lili, Zheng, Weiping, Wang, Zhenghe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671608/
https://ncbi.nlm.nih.gov/pubmed/23643389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.021
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