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A mechanism-based potent sirtuin inhibitor containing N(ε)-thiocarbamoyl-lysine (TuAcK)

In the current study, we have identified N(ε)-thiocarbamoyl-lysine (TuAcK) as a general sirtuin inhibitory warhead which was shown to be able to confer potent sirtuin inhibition. This inhibition was also shown to be mechanism-based in that the TuAck residue was able to be processed by a sirtuin enzy...

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Autors principals: Hirsch, Brett M., Hao, Yujun, Li, Xiaopeng, Wesdemiotis, Chrys, Wang, Zhenghe, Zheng, Weiping
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146582/
https://ncbi.nlm.nih.gov/pubmed/21752644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.069
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