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A mechanism-based potent sirtuin inhibitor containing N(ε)-thiocarbamoyl-lysine (TuAcK)
In the current study, we have identified N(ε)-thiocarbamoyl-lysine (TuAcK) as a general sirtuin inhibitory warhead which was shown to be able to confer potent sirtuin inhibition. This inhibition was also shown to be mechanism-based in that the TuAck residue was able to be processed by a sirtuin enzy...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3146582/ https://ncbi.nlm.nih.gov/pubmed/21752644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.06.069 |
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