A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

BACKGROUND: There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study (GWAS) data across several traits, usually at the summary statistic level. A major practical chal...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: LeBlanc, Marissa, Zuber, Verena, Thompson, Wesley K., Andreassen, Ole A., Frigessi, Arnoldo, Andreassen, Bettina Kulle
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019513/
https://ncbi.nlm.nih.gov/pubmed/29940862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-018-4859-7
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