Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction

In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity and function. However, increased inflammation in the DEJ is associated with the disruption and separation of this junction and sub-epidermal...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Russo, Valerio, Klein, Theo, Lim, Darielle J., Solis, Nestor, Machado, Yoan, Hiroyasu, Sho, Nabai, Layla, Shen, Yue, Zeglinski, Matthew R., Zhao, Hongyan, Oram, Cameron P., Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Crawford, Richard I., Franzke, Claus-Werner, Overall, Christopher M., Granville, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6018769/
https://ncbi.nlm.nih.gov/pubmed/29946113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28070-0
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi