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Topical small molecule granzyme B inhibitor improves remodeling in a murine model of impaired burn wound healing

Granzyme B (GzmB) is a serine protease that has long been thought to function exclusively in lymphocyte-mediated apoptosis. In recent years, this paradigm has been revisited due to the recognition that GzmB accumulates in the extracellular milieu in many autoimmune and chronic inflammatory disorders...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Shen, Yue, Zeglinski, Matthew R., Turner, Christopher T., Raithatha, Sheetal A., Wu, Zhenguo, Russo, Valerio, Oram, Cameron, Hiroyasu, Sho, Nabai, Layla, Zhao, Hongyan, Bozin, Tatjana, Westendorf, Kathryn, Kopko, Irina, Huang, Rachel, Arns, Steve, Tan, Jason, Zeng, Haishan, Boey, Anthony, Liggins, Richard, Jaquith, James, Cameron, Dale R., Papp, Anthony, Granville, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976625/
https://ncbi.nlm.nih.gov/pubmed/29849046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-018-0095-0
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