Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture

Decorin (DCN) is a small-leucine rich proteoglycan that mediates collagen fibrillogenesis, organization, and tensile strength. Adventitial DCN is reduced in abdominal aortic aneurysm (AAA) resulting in vessel wall instability thereby predisposing the vessel to rupture. Recombinant DCN fusion protein...

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Publicado no:Sci Rep
Main Authors: Shen, Yue, Russo, Valerio, Zeglinski, Matthew R., Sellers, Stephanie L., Wu, Zhengguo, Oram, Cameron, Santacruz, Stephanie, Merkulova, Yulia, Turner, Christopher, Tauh, Keerit, Zhao, Hongyan, Bozin, Tatjana, Bohunek, Lubos, Zeng, Haishan, Seidman, Michael A., Bleackley, R. Chris, McManus, Bruce M., Ruoslahti, Erkki, Järvinen, Tero A. H., Granville, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5696466/
https://ncbi.nlm.nih.gov/pubmed/29158532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16194-8
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