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Generation of a multi‐functional, target organ‐specific, anti‐fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin

ABSTRACT: Extracellular matrix (ECM) molecules play important roles in regulating processes such as cell proliferation, migration, differentiation and survival. Decorin is a proteoglycan that binds to (‘decorates’) collagen fibrils in the ECM. Decorin also interacts with many growth factors and thei...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Järvinen, Tero A H, Ruoslahti, Erkki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284330/
https://ncbi.nlm.nih.gov/pubmed/29847688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14374
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