Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Pemphigoid diseases refer to a group of severe autoimmune skin blistering diseases characterized by subepidermal blistering and loss of dermal-epidermal adhesion induced by autoantibody and immune cell infiltrate at the dermal-epidermal junction and upper dermis. Here, we explore the role of the imm...

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Publicado no:Nat Commun
Main Authors: Hiroyasu, Sho, Zeglinski, Matthew R., Zhao, Hongyan, Pawluk, Megan A., Turner, Christopher T., Kasprick, Anika, Tateishi, Chiharu, Nishie, Wataru, Burleigh, Angela, Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Petersen, Frank, Crawford, Richard I., Shimizu, Hiroshi, Tsuruta, Daisuke, Ludwig, Ralf J., Granville, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804321/
https://ncbi.nlm.nih.gov/pubmed/33436591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20604-3
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