Granzyme B inhibition reduces disease severity in autoimmune blistering diseases

Pemphigoid diseases refer to a group of severe autoimmune skin blistering diseases characterized by subepidermal blistering and loss of dermal-epidermal adhesion induced by autoantibody and immune cell infiltrate at the dermal-epidermal junction and upper dermis. Here, we explore the role of the imm...

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Vydáno v:Nat Commun
Hlavní autoři: Hiroyasu, Sho, Zeglinski, Matthew R., Zhao, Hongyan, Pawluk, Megan A., Turner, Christopher T., Kasprick, Anika, Tateishi, Chiharu, Nishie, Wataru, Burleigh, Angela, Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Petersen, Frank, Crawford, Richard I., Shimizu, Hiroshi, Tsuruta, Daisuke, Ludwig, Ralf J., Granville, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7804321/
https://ncbi.nlm.nih.gov/pubmed/33436591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20604-3
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