Retinal Distribution and Extracellular Activity of Granzyme B: A Serine Protease That Degrades Retinal Pigment Epithelial Tight Junctions and Extracellular Matrix Proteins

Granzymes are a family of serine proteases first shown to be intracellular initiators of immune-mediated cell death in target pathogenic cells. In addition to its intracellular role, Granzyme B (GzmB) has important extracellular functions in immune regulation and extracellular matrix (ECM) degradati...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Matsubara, Joanne A., Tian, Yuan, Cui, Jing Z., Zeglinski, Matthew R., Hiroyasu, Sho, Turner, Christopher T., Granville, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155911/
https://ncbi.nlm.nih.gov/pubmed/32318066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00574
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