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Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription

In order to explore the defense mechanism by which retrotransposons are repressed, we assessed the ability of methyl-CpG-binding protein 2, MeCP2, to influence LINE-1 (L1) and Alu transcription and, furthermore, L1 retrotransposition. In transient transfection assays, targeting of the transcriptiona...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yu, Fang, Zingler, Nora, Schumann, Gerald, Strätling, Wolf H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC60185/
https://ncbi.nlm.nih.gov/pubmed/11691937
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