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The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states

<p>Abstract</p> <p>Background</p> <p>DNA CpG methylation is carried out by DNA methyltransferases and induces chromatin remodeling and gene silencing through a transcription repressor complex comprising the methyl-CpG-binding protein 2 (MeCP2) and a subset of histone deacetylases. Recently, we have...

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Main Authors: Tochiki Keri K, Cunningham Joel, Hunt Stephen P, Géranton Sandrine M
Format: Artigo
Language:Inglês
Published: SAGE Publishing 2012-02-01
Series:Molecular Pain
Subjects:
MeCP2
Astrocyte
Microglia
Spinal nerve injury
Inflammation
Chronic pain
DNA methyltransferase
Histone deacetylase
Online Access:http://www.molecularpain.com/content/8/1/14
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