Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental “shock-and-kill” therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected cell elim...

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Principais autores:	Donya Naz Divsalar, Conrad Veranso Simoben, Cole Schonhofer, Khumoekae Richard, Wolfgang Sippl, Fidele Ntie-Kang, Ian Tietjen
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2020-06-01
סדרה:	Frontiers in Pharmacology
נושאים:	virtual screening histone deacetylase histone deacetylase inhibitor HIV latency reversal drug discovery
גישה מקוונת:	https://www.frontiersin.org/article/10.3389/fphar.2020.00905/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!