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Structure–Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer

A series of phosphoramidate-based prostate specific membrane antigen (PSMA) inhibitors of increasing lipophilicity were synthesized (4, 5, and 6), and their fluorine-18 analogs were evaluated for use as positron emission tomography (PET) imaging agents for prostate cancer. To gain insight into their...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Dannoon, Shorouk, Ganguly, Tanushree, Cahaya, Hendry, Geruntho, Jonathan J., Galliher, Matthew S., Beyer, Sophia K., Choy, Cindy J., Hopkins, Mark R., Regan, Melanie, Blecha, Joseph E., Skultetyova, Lubica, Drake, Christopher R., Jivan, Salma, Barinka, Cyril, Jones, Ella F., Berkman, Clifford E., VanBrocklin, Henry F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016545/
https://ncbi.nlm.nih.gov/pubmed/27228467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01850
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