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Structure–Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer

A series of phosphoramidate-based prostate specific membrane antigen (PSMA) inhibitors of increasing lipophilicity were synthesized (4, 5, and 6), and their fluorine-18 analogs were evaluated for use as positron emission tomography (PET) imaging agents for prostate cancer. To gain insight into their...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Dannoon, Shorouk, Ganguly, Tanushree, Cahaya, Hendry, Geruntho, Jonathan J., Galliher, Matthew S., Beyer, Sophia K., Choy, Cindy J., Hopkins, Mark R., Regan, Melanie, Blecha, Joseph E., Skultetyova, Lubica, Drake, Christopher R., Jivan, Salma, Barinka, Cyril, Jones, Ella F., Berkman, Clifford E., VanBrocklin, Henry F.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016545/
https://ncbi.nlm.nih.gov/pubmed/27228467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01850
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