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Synthesis and Evaluation of Constrained Phosphoramidate Inhibitors of Prostate-Specific Membrane Antigen

Prostate-specific membrane antigen (PSMA) is a cell-surface enzyme-biomarker that is actively pursued for targeted delivery of imaging and therapeutic agents for prostate cancer. Our lab has developed PSMA inhibitors based on a phosphoramidate scaffold, which has shown both high selectivity for PSMA...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Ley, Corinne R., Beattie, Nathan R., Dannoon, Shorouk, Regan, Melanie, VanBrocklin, Henry, Berkman, Clifford E.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588815/
https://ncbi.nlm.nih.gov/pubmed/25956413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.04.047
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