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Thrombospondin-1 regulation of latent TGF-β activation: a therapeutic target for fibrotic disease

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with global inhibitors of TGF-β have been disappointing, suggesting that a more targeted approach is warranted. Conversion of the latent precursor to the biologically active form of TGF-β represents a novel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Matrix Biol
Prif Awduron: Murphy-Ullrich, Joanne E., Suto, Mark J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6015530/
https://ncbi.nlm.nih.gov/pubmed/29288716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2017.12.009
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