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Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-β activation

Transforming growth factor-β (TGF-β) is a critical regulator of bone development and remodeling. TGF-β must be activated from its latent form in order to signal. Thrombospondin-1 (TSP1) is a major regulator of latent TGF-β activation and TSP1 control of TGF-β activation is critical for regulation of...

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Bibliografiske detaljer
Main Authors: DuBose, Kimberly Bailey, Zayzafoon, Majd, Murphy-Ullrich, Joanne E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372697/
https://ncbi.nlm.nih.gov/pubmed/22583901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.05.020
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