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Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms
Thrombospondin 1(TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and plays a role in wound healing and fibrosis. Binding of the TSP N-terminal domain to cell surface calreticulin in complex with...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3295861/ https://ncbi.nlm.nih.gov/pubmed/22266026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2012.01.006 |
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