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Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

Thrombospondin 1(TSP1) plays major roles in both physiologic and pathologic tissue repair. TSP1 through its type 1 repeats is a known regulator of latent TGF-β activation and plays a role in wound healing and fibrosis. Binding of the TSP N-terminal domain to cell surface calreticulin in complex with...

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Main Authors: Sweetwyne, Mariya T., Murphy-Ullrich, Joanne E.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3295861/
https://ncbi.nlm.nih.gov/pubmed/22266026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2012.01.006
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