Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancer

Liver diseases is a growing epidemic worldwide. If unresolved, liver fibrosis develops and can lead to cirrhosis and clinical decompensation. Around 5% of cirrhotic liver diseased patients develop hepatocellular carcinoma (HCC), which in its advanced stages has limited therapeutic options and negati...

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Библиографические подробности
Опубликовано в: :Oncogene
Главные авторы: Reebye, Vikash, Huang, Kai-Wen, Lin, Vivian, Jarvis, Sheba, Cutilas, Pedro, Dorman, Stephanie, Ciriello, Simona, Andrikakou, Pinelopi, Voutila, Jon, Saetrom, Pal, Mintz, Paul J, Reccia, Isabella, Rossi, John J, Huber, Hans, Habib, Robert, Kostomitsopoulos, Nikos, Blakey, David, Habib, Nagy
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013054/
https://ncbi.nlm.nih.gov/pubmed/29511346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0126-2
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