Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

Small activating RNAs (saRNAs) are short double-stranded oligonucleotides that selectively increase gene transcription. Here, we describe the development of an saRNA that upregulates the transcription factor CCATT/enhancer binding protein alpha (CEBPA), investigate its mode of action, and describe i...

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Vydáno v:Mol Ther
Hlavní autoři: Voutila, Jon, Reebye, Vikash, Roberts, Thomas C., Protopapa, Pantelitsa, Andrikakou, Pinelopi, Blakey, David C., Habib, Robert, Huber, Hans, Saetrom, Pal, Rossi, John J., Habib, Nagy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768526/
https://ncbi.nlm.nih.gov/pubmed/28882451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.07.018
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