Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice

Excessive or inappropriate inflammatory responses can cause serious and even fatal diseases. The CCAAT/enhancer-binding protein alpha (CEBPA) gene encodes C/EBPα, a transcription factor that plays a fundamental role in controlling maturation of the myeloid lineage and is also expressed during the la...

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Udgivet i:Mol Ther
Main Authors: Zhou, Jiehua, Li, Haitang, Xia, Xin, Herrera, Alberto, Pollock, Nicolette, Reebye, Vikash, Sodergren, Mikael H., Dorman, Stephanie, Littman, Bruce H., Doogan, Declan, Huang, Kai-Wen, Habib, Robert, Blakey, David, Habib, Nagy A., Rossi, John J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520465/
https://ncbi.nlm.nih.gov/pubmed/30852139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.02.018
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