EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS

In a previous study we identified two molecular groups of supratentorial (ST) ependymoma in pediatric patients driven by distinct gene fusions involving either the NF-κB effector RELA or the HIPPO signaling regulator YAP1, designated ST-EPN-RELA and ST-EPN-YAP1, respectively. The lack of adequate mo...

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Published in:Neuro Oncol
Main Authors: Pajtler, Kristian W, Okonechnikov, Konstantin, Vouri, Mikaella, Brabetz, Sebastian, Jones, David T W, Korshunov, Andrey, Capper, David, Chavez, Lukas, Pfister, Stefan M, Kool, Marcel, Kawauchi, Daisuke
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012928/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.224
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