YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

YAP1 fusion-positive supratentorial ependymomas predominantly occur in infants, but the molecular mechanisms of oncogenesis are unknown. Here we show YAP1-MAMLD1 fusions are sufficient to drive malignant transformation in mice, and the resulting tumors share histo-molecular characteristics of human...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei, Kawauchi, Daisuke
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718408/
https://ncbi.nlm.nih.gov/pubmed/31477715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11884-5
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia