DIPG-66. THE H3K27M MUTATION CAUSES WIDE-RANGING CHANGES MEDIATING DIPG TUMORIGENESIS

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a nearly uniformly fatal pediatric brain tumor. 80% of DIPGs harbor a mutation (K27M) in genes encoding histones H3.1 or H3.3. We aimed to clarify the role of this mutation in tumorigenesis. METHODS: We transduced adult glioblastoma, pediatric g...

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Publicado en:Neuro Oncol
Autores principales: Lemma, Rakeb, DeSisto, John, Flannery, Patrick, Sanford, Bridget, Balakrishnan, Ilango, Madhavan, Krishna, Veo, Bethany, Levy, Jean Mulcahy, Foreman, Nicholas, Vibhakar, Rajeev, Jones, Kenneth, Venkataraman, Sujatha, Green, Adam
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012785/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.159
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