DIPG-79. H3K27M INDUCES EPIGENETIC AND ONCOGENIC CHANGES THAT ARE PARTIALLY REVERSED BY SMALL MOLECULE AURORA KINASE B/C INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor with no curative treatments. Approximately 80% of DIPGs contain an H3K27M mutation. The implications of the mutation and how they may be targeted are not fully understood. We established an H3K27M effect-isolating model by tran...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Chatwin, Hannah, Lemma, Rakeb, DeSisto, John, Knox, Aaron, Mestnik, Shelby, Reid, Aidan, Vibhakar, Rajeev, Venkataraman, Sujatha, Green, Adam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Diffuse Midline Glioma/DIPG
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715821/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.121
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