HGG-25. PRMT5 PROMOTES TUMOR GROWTH BY MAINTAINING STEMNESS OF PEDIATRIC HIGH-GRADE GLIOMA CELLS

BACKGROUND: Pediatric high-grade gliomas (pHGG) are aggressive tumors that together constitute the most common cause of childhood cancer mortality. Tumor stem cells that drive proliferation of pHGG resist chemotherapy and radiation, complicating treatment. The arginine methyltransferase PRMT5 mainta...

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Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: DeSisto, John, Knox, Aaron, Chatwin, Hannah, Balakrishnan, Ilango, Venkataraman, Sujatha, Vibhakar, Rajeev, Green, Adam
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2021
Aiheet:
High Grade Gliomas
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168078/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.089
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