DIPG-73. SENESCENCE ASSOCIATED SECRETORY PHENOTYPE AS A MECHANISM OF RESISTANCE AND THERAPEUTIC VULNERABILITY IN BMI1 INHIBITOR TREATED DIPG

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) driven by mutations in the histone 3 (H3) gene (H3K27M) are aggressive pediatric brain tumors for which there is no curative therapy. METHODS: To identify novel therapeutic targets we performed a high throughput drug screen combined with an epige...

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Publicado no:Neuro Oncol
Main Authors: Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Bridget, Sanford, Birks, Diane K, Davidson, Nate, Metselaar, Dennis S, Neel, Hans, Donson, Andrew, Griesinger, Andrea, Katagi, Hiroaki, Vijmasi, Trinka, Sola, Ismail, Alimova, Irina, Fosmire, Susan, Hulleman, Esther, Serkova, Natalie J, Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel Montero, Gupta, Nalin, Jones, Ken, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Diffuse Midline Glioma/DIPG
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715943/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.115
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