DIPG-73. SENESCENCE ASSOCIATED SECRETORY PHENOTYPE AS A MECHANISM OF RESISTANCE AND THERAPEUTIC VULNERABILITY IN BMI1 INHIBITOR TREATED DIPG

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) driven by mutations in the histone 3 (H3) gene (H3K27M) are aggressive pediatric brain tumors for which there is no curative therapy. METHODS: To identify novel therapeutic targets we performed a high throughput drug screen combined with an epige...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Neuro Oncol
Κύριοι συγγραφείς: Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Bridget, Sanford, Birks, Diane K, Davidson, Nate, Metselaar, Dennis S, Neel, Hans, Donson, Andrew, Griesinger, Andrea, Katagi, Hiroaki, Vijmasi, Trinka, Sola, Ismail, Alimova, Irina, Fosmire, Susan, Hulleman, Esther, Serkova, Natalie J, Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel Montero, Gupta, Nalin, Jones, Ken, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2020
Θέματα:
Diffuse Midline Glioma/DIPG
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715943/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.115
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