Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

Diffuse intrinsic pontine glioma (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective treatment for this tumor. Using a combined RNAi and chemical screen targeting epi...

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Publicat a:Cell Rep
Autors principals: Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Sanford, Bridget, Birks, Diane K., Davidson, Nate, Metselaar, Dennis S., Meel, Michaël Hananja, Lemma, Rakeb, Donson, Andrew, Vijmasi, Trinka, Katagi, Hiroaki, Sola, Ismail, Fosmire, Susan, Alimova, Irina, Steiner, Jenna, Gilani, Ahmed, Hulleman, Esther, Serkova, Natalie J., Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel M., Gupta, Nalin, Monje, Michelle, Jabado, Nada, Jones, Kenneth, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7574900/
https://ncbi.nlm.nih.gov/pubmed/33086074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108286
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