DIPG-77. INTRATUMORAL PHARMACOKINETICS OF CHEMOTHERAPY IN DIPG: XENOGRAFT AND INITIAL PHASE 0 CLINICAL TRIAL RESULTS

INTRODUCTION: Hundreds of chemotherapy trials have been conducted in diffuse intrinsic pontine glioma (DIPG) without survival improvement. One potential reason is a lack of intratumoral penetration, but this has not previously been assessed in humans. We used gemcitabine as a model agent to assess D...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Green, Adam, Flannery, Patrick, Hankinson, Todd, O’Neill, Brent, DeSisto, John, Lemma, Rakeb, Hoffman, Lindsey, Levy, Jean Mulcahy, Raybin, Jennifer, Hemenway, Molly, Koschmann, Carl, Handler, Michael, Foreman, Nicholas, Vibhakar, Rajeev, Wempe, Michael, Dorris, Kathleen
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012608/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.169
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