Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine

BACKGROUND: Hundreds of systemic chemotherapy trials in diffuse intrinsic pontine glioma (DIPG) have not improved survival, potentially due to lack of intratumoral penetration, which has not previously been assessed in humans. METHODS: We used gemcitabine as a model agent to assess DIPG intratumoral...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Green, Adam L, Flannery, Patrick, Hankinson, Todd C, O’Neill, Brent, Amani, Vladimir, DeSisto, John, Knox, Aaron, Chatwin, Hannah, Lemma, Rakeb, Hoffman, Lindsey M, Mulcahy Levy, Jean, Raybin, Jennifer, Hemenway, Molly, Gilani, Ahmed, Koschmann, Carl, Dahl, Nathan, Handler, Michael, Pierce, Angela, Venkataraman, Sujatha, Foreman, Nicholas, Vibhakar, Rajeev, Wempe, Michael F, Dorris, Kathleen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212907/
https://ncbi.nlm.nih.gov/pubmed/32642682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa021
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